DIABETES MELLITUS IN VETERINARY MEDICINE: A CURRENT OVERVIEW OF ALTERNATIVE AND SUPPORTIVE TREATMENT STRATEGIES
Keywords:
Diabetes mellitus, veterinary medicine, alternative therapy, herbal treatment, glycemic controlAbstract
Diabetes mellitus (DM) is a significant endocrinological disease with an increasing prevalence in both humans and animals. This condition, which is especially common in pets such as cats and dogs, reduces the quality of life and can lead to serious complications. Although conventional treatment methods (insulin applications, dietary management) have an important place in the management of the disease, factors such as difficulties in achieving glycemic control, side effects, treatment compliance problems and cost increase the interest in alternative and supportive treatment strategies. This review aims to summarize the prevalence, pathogenesis, clinical symptoms and conventional treatment approaches of DM in veterinary medicine; afterward to evaluate alternative and supportive treatment strategies such as phytotherapy and other complementary methods, scientific evidence in this field, mechanisms of action, efficacy and safety studies from the perspective of pharmacology and toxicology. This study, prepared in line with the scientific literature, provides an up-to-date view of potential new approaches and future research that can be used in the management of diabetes in veterinary medicine.
References
[1] Khursheed, R., Singh, S. K., Wadhwa, S., Kapoor, B., Gulati, M., Kumar, R., Dua, K. (2019): Treatment strategies against diabetes: Success so far and challenges ahead. European Journal of Pharmacology 862: 172625.
[2] Andrade, C., Gomes, N. G. M., Duangsrisai, S., Andrade, P. B., Pereira, D. M., Valentão, P. (2020): Medicinal plants utilized in Thai Traditional Medicine for diabetes treatment: Ethnobotanical surveys, scientific evidence and phytochemicals. Journal of Ethnopharmacology 263: 113177.
[3] Choudhury, H., Kumar, S., Gorain, B., Pandey, M., Chatterjee, S. K., & Pal, J. (2018a). Role of medicinal plants in management of diabetes mellitus and its complications: A review. Journal of Herbal Medicine 14: 46-56.
[4] Gilor, C., Niessen, S. J. M., Furrow, E., DiBartola, S. P. (2016a). What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters. Journal of Veterinary Internal Medicine 30: 927-940.
[5] Hoening, M. (2014): Carbohydrate Metabolism and Pathogenesis of Diabetes Mellitus in Dogs and Cats. In A. C. Normal & D. R. Robert (ed.) Canine and Feline Endocrinology and Reproduction, Elsevier Saunders, Illinois, USA.
[6] Sparkes, A. H., Chair, P., Cannon, M., Church, D., Fleeman, L., Harvey, A., Hoenig, M., Peterson, M. E., Reusch, C. E., Taylor, S., Rosenberg, D. (2015): ISFM consensus guidelines on the practical management of diabetes mellitus in cats. Journal of Feline Medicine and Surgery 17: 235-250.
[7] Laflamme, D. P. (2005): Nutrition for aging cats and dogs and the importance of body condition. Veterinary Clinics: Small Animal Practice 35: 713-742.
[8] Kleinert, M., Clemmensen, C., Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Tschöp, M. H. (2018). Animal models of obesity and diabetes mellitus. Nature Reviews Endocrinology 14: 140-162.
[9] Cook, A.K., Behrend, E. (2024): SGLT2 inhibitor use in the management of feline diabetes mellitus. Journal of Veterinary Pharmacology and Therapeutics 48: 19-30.
[10] Jena, G. R. (2016): Prevalence, clinico-biochemical and therapeutics of diabetes mellitus in dogs. (PhD Thesis). Orissa University of Agriculture and Technology, Bhubaneswar, India.
[11] Niaz, K., Makbul, F., Han, F., Hassan, F. I., Momtaz, S., Abdollahi, M. (2018): Incidence of diabetes and its association with pancreatic diseases and ketoacidosis in dogs, cats, and a few wild animals compared to therapeutic approaches. Veterinary World 11: 410
[12] Majhi, S., Singh, L., Verma, M., Chauhan, I., Sharma, M. (2022a): In-vivo evaluation and formulation development of polyherbal extract in streptozotocin-induced diabetic rat. Phytomedicine Plus 2: 100337.
[13] Gilor, C., Rudinsky, A.J., Hall, M.J. (2016b): Glucagon-like peptide-1-based treatments in feline diabetes mellitus. Journal of Feline Medicine and Surgery 18: 541-547.
[14] Nelson, R. W. (1996): Treatment of diabetes mellitus in dogs and cats. Veterinary Quarterly 18: 27-29.
[15] Tardo, A. M., Fleeman, L. M., Fracassi, F., Berg, A. S., Guarino, A. L., Gilor, C. (2024): A dose titration protocol for once-daily insulin glargine 300 U/mL for the treatment of diabetes mellitus in dogs. Journal of Veterinary Internal Medicine 38: 2120-2128.
[16] Hoelmkjaer, K.M., Spodsberg, E.M., Bjornvad, C.R. (2015): Insulin detemir treatment in diabetic cats in a practice setting. Journal of Feline Medicine and Surgery 17: 144-151.
[17] Hulsebosch, S.E., Pires, J., Bannasch, M.J., Chen, C., Duran-Struuck, R., Hinder, M., Kirk, C.A., Gilor, C. (2022): Ultra-long-acting recombinant insulin for the treatment of diabetes mellitus in dogs. Journal of Veterinary Internal Medicine 36: 1211-1219.
[18] Elliott, K.F., Rand, J.S., Fleeman, L.M., Morton, J.M., Litster, A.L., Biourge, V.C., Sunvold, G.D. (2012): A diet lower in digestible carbohydrate results in lower postprandial glucose concentrations compared with a traditional canine diabetes diet and an adult maintenance diet in healthy dogs. Research in Veterinary Science 93: 288-295.
[19] Carciofi, A.C., Takakura, F.S., de-Oliveira, L.D., Teshima, E., Jeremias, J.T., Brunetto, M.A., Prada, F. (2008): Effects of six carbohydrate sources on dog diet digestibility and post-prandial glucose and insulin response. Journal of Animal Physiology and Animal Nutrition 92: 326-336.
[20] Setiyorini, E., Qomaruddin, M. B., Wibisono, S., Juwariah, T., Setyowati, A., Wulandari, N. A., Sari, L. T (2022): Complementary and alternative medicine for glycemic control of diabetes mellitus: A systematic review. Journal of Public Health Research 11: 22799036221106582.
[21] Yoon, G., Kwong, R. Y., Chien, D., Hwang, P. M. (2007): Metformin in the treatment of obesity in dogs: A prospective, randomized, double-blind, placebo-controlled study. Journal of Veterinary Internal Medicine 21: 903-908.
[22] Zini, E., Hafner, M., Osto, M., Franchini, M., Ackermann, M., Lutz, T. A., Reusch, C. E. (2010): Predictors of clinical remission in cats with diabetes mellitus. Journal of Veterinary Internal Medicine 24: 1314-1321.
[23] Tinworth, K. D., Harris, P. A., Sillence, M. N., Noble, G. K. (2010): Potential treatments for insulin resistance in the horse: A comparative multi-species review. The Veterinary Journal 186: 282-291.
[24] Zeugswetter, F., Pagitz, M. (2009): Ketone measurements using dipstick methodology in cats with diabetes mellitus. Journal of Small Animal Practice 50: 4-8.
[25] Choudhury, H., Pandey, M., Hua, C.K., Mun, C.S., Jing, J.K., Kong, L., Ern, L.Y., Ashraf, N.A., Kit, S.W., Yee, T.S., Pichika, M.R., Gorain, B., Kesharwani, P. (2018b): An update on natural compounds in the remedy of diabetes mellitus: A systematic review. Journal of Traditional and Complementary Medicine, 8: 361-376.
[26] Gushiken, L.F., Beserra, F.P., Rozza, A.L., Bérgamo, P.L., Bérgamo, D.A., Pellizzon, C.H. (2016): Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects. The Review of Diabetic Studies 13: 82–97.
[27] Khan, W., Zahiruddin, S., Ahmad, S. (2020): Diabetes-associated complications and some Indian traditional plants used for its management. Studies in Natural Products Chemistry 66: 117-155.
[28] Tran, N., Pham, B., Le, L. (2020): Bioactive compounds in anti-diabetic plants: From herbal medicine to modern drug discovery. Biology 9: 252.
[29] Patel, S. S., Shah, R. S., Goyal, R. K. (2012): Antidiabetic activity of Gymnema sylvestre leaves extract in streptozotocin induced diabetic rats. Journal of Natural Remedies 12: 8-15.
[30] Shanmugasundaram, E. R., Rajeswari, G., Baskaran, K., Kumar, B. R., Shanmugasundaram, K. R., Ahmath, K. A. (1990): Use of Gymnema sylvestre leaf extract in the control of hyperglycaemia in insulin-dependent diabetes mellitus. Journal of Ethnopharmacology 30: 281-294.
[31] Al‐Romaiyan, A., King, A. J., Persaud, S. J., Jones, P. M. (2013): A novel extract of Gymnema sylvestre improves glucose tolerance in vivo and stimulates insulin secretion and synthesis in vitro. Phytotherapy Research 27: 1006-1011.
[32] Kumar, S. N., Mani, U. V., Mani, I. (2010): An open label study on the supplementation of Gymnema sylvestre in type 2 diabetics. Journal of Dietary Supplements 7: 273-282.
[33] Khan, F., Sarker, M. M. R., Ming, L. C., Mohamed, I. N., Zhao, C., Sheikh, B. Y., Rashid, M. A. (2019): Comprehensive review on phytochemicals, pharmacological and clinical potentials of Gymnema sylvestre. Frontiers in Pharmacology 10: 1223.
[34] Liu, Z., Gong, J., Huang, W., Lu, F., Dong, H. (2021): The effect of Momordica charantia in the treatment of diabetes mellitus: A review. Evidence‐Based Complementary and Alternative Medicine 2021: 3796265.
[35] Raman, A., Lau, C. (1996): Anti-diabetic properties and phytochemistry of Momordica charantia L.(Cucurbitaceae). Phytomedicine 2: 349-362.
[36] Gupta, V. (2013): Glucagon-like peptide-1 analogues: an overview. Indian Journal of Endocrinology and Metabolism 17: 413-421.
[37] Xue, W. L., Li, X. S., Zhang, R. J. (2007): Effect of fenugreek on blood glucose and insulin in alloxan-induced diabetic mice. Journal of Ethnopharmacology 110: 441-446.
[38] Singhal, S., Rathore, A. S., Lohar, V., Dave, R., Dave, J. (2014): Pharmacological evaluation of “sugar remedy,” a polyherbal formulation, on streptozotocin-induced diabetic mellitus in rats. Journal of Traditional and Complementary Medicine 4: 189-195.
[39] Basch, E., Ulbricht, C., Kuo, G., Szapary, P., Smith, M. (2003): Therapeutic applications of fenugreek. Alternative Medicine Review 8: 20-27.
[40] Sharma, R. D., Raghuram, T. C., Rao, N. S. (1990): Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. European Journal of Clinical Nutrition 44: 301-306.
[41] Vats, V., Grover, J. K., Rathi, S. S. (2002): Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats. Journal of Ethnopharmacology 79: 95-100.
[42] Pradeep, S. R., Barman, S., Srinivasan, K. (2019): Attenuation of diabetic nephropathy by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) via suppression of glucose transporters and renin-angiotensin system. Nutrition 67: 110543.
[43] Bahmani, M., Shirzad, H., Mirhosseini, M., Mesripour, A., Rafieian-Kopaei, M. (2016): A review on ethnobotanical and therapeutic uses of fenugreek (Trigonella foenum-graceum L). Journal of Evidence-Based Complementary & Alternative medicine, 21: 53-62.
[44] Visuvanathan, T., Than, L. T. L., Stanslas, J., Chew, S. Y., Vellasamy, S. (2022): Revisiting Trigonella foenum-graecum L.: pharmacology and therapeutic potentialities. Plants 11: 1450.
[45] Anderson, R. A., Broadhurst, C. L., Polansky, M. M., Schmidt, W. F., Miura, A., Flanagan, N. P., Graves, D. J. (2004): Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. Journal of Agricultural and Food Chemistry 52: 65-70.
[46] Jarvill-Taylor, K. J., Anderson, R. A., Graves, D. J. (2001): A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. Journal of the American College of Nutrition 20: 327-336.
[47] Kim, S. H., Hyun, S. H., Choung, S. Y. (2006): Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. Journal of Ethnopharmacology 104: 119-123.
[48] Sartorius, T., Peter, A., Schulz, N., Drescher, A., Bergheim, I., Machann, J., Hennige, A. M. (2014): Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity. PloS one 9: e92358.
[49] Mahomoodally, M. F. (2013): Traditional medicines in Africa: an appraisal of ten potent African medicinal plants. Evidence‐Based Complementary and Alternative Medicine 2013: 617459.
[50] Xie, J. T., Mehendale, S. R., Li, X., Quigg, R., Wang, X., Wang, C. Z., Yuan, C. S. (2005): Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1740: 319-325.
[51] Yang, Z., Wang, D., Li, Y., Zhou, X., Liu, T., Shi, C., Wu, X. (2022): Untargeted metabolomics analysis of the anti-diabetic effect of Red ginseng extract in Type 2 diabetes Mellitus rats based on UHPLC-MS/MS. Biomedicine & Pharmacotherapy 146: 112495.
[52] Attele, A. S., Zhou, Y. P., Xie, J. T., Efferth, T., Wang, G., Zhang, S., Yuan, C. S. (2002): Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51: 1851-1858.
[53] Yuan, H. D., Chung, S. H. (2010): Protective effects of fermented ginseng on streptozotocin-induced pancreatic β-cell damage through inhibition of NF-κB. International Journal of Molecular Medicine 25: 53-58.
[54] Shen, L., Qi, J., He, J. (2018): Ginsenoside Rb2 promotes glucose metabolism and attenuates fat accumulation via AKT-dependent mechanisms. Molecules 23: 29425748.
[55] Yin, J., Xing, H., Ye, J. (2002): Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 51: 1528-1532.
[56] Kong, W. J., Zhang, H., Song, D. Q., Xue, R., Zhao, W., Wei, J., Jiang, J. D. (2009): Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression. Metabolism 58: 109-119.
[57] Raut, N. A., Dhore, P. W., Saoji, S. D., Kokare, D. M. (2016): Selected bioactive natural products for diabetes mellitus. Studies in Natural Products Chemistry 48: 287-322.
[58] Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Kim, J. B. (2006): Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55: 2256-2264.
[59] Yin, J., Zhang, J., Ye, J. (2008): Berberine improves glucose metabolism through induction of glycolysis. Molecular and Cellular Endocrinology, 292: 177-183.
[60] Zhou, L., Wang, X., Shao, L., Yang, Y., Shang, W., Yuan, G., Jiang, B., Li, F., Tang, J., Jing, H., Chen, M. (2008): Berberine Acutely Inhibits Insulin Secretion from β-Cells through 3′,5′-Cyclic Adenosine 5′-Monophosphate Signaling Pathway. Endocrinology 149: 4510-4519.
[61] Mathew, P. T., Augusti, K. T. (1975). Hypoglycaemic effects of onion, Allium cepa Linn. on diabetes mellitus-a preliminary report. Indian Journal of Physiology and Pharmacology 19: 213-217.
[62] Thomson, M., Alnaqeeb, M. A., Bordia, T., Al-Hassan, J. M., Afzal, M., Ali, M. (1998): Effects of aqueous extract of onion on the liver and lung of rats. Journal of Ethnopharmacology 61: 91-99.
[63] Ohaeri, O. C. (2001). Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats. Bioscience Reports 21: 19-24.
[64] Eidi, A., Eidi, M., Esmaeili, R. (2006): Antidiabetic effect of garlic (Allium sativum L.) in streptozotocin-induced diabetic rats. Phytomedicine 13: 624-629.
[65] Ojieh, A. E., Adegor, E. C., Okolo, A. C., Lawrence, E. O., Njoku, I. P., Onyekpe, C. U. (2015): Hypoglycemic and hypolipidaemic effect of allium cepa in streptozotocin-induced diabetes. International Journal of Science and Engineering 6: 23-29.
[66] Theodorakopoulou, A., Pylarinou, I., Anastasiou, I. A., Tentolouris, N. (2025). The Putative Antidiabetic Effect of Hypericum perforatum on Diabetes Mellitus. International Journal of Molecular Sciences 26: 354.
[67] Novelli, M., Masiello, P., Beffy, P., Menegazzi, M. (2020): Protective role of St. John’s wort and its components hyperforin and hypericin against diabetes through inhibition of inflammatory signaling: Evidence from in vitro and in vivo studies. International Journal of Molecular Sciences 21: 8108.
[68] Arokiyaraj, S., Balamurugan, R., Augustian, P. (2011): Antihyperglycemic effect of Hypericum perforatum ethyl acetate extract on streptozotocin–induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine 1: 386-390.
[69] Ibaokurgil, F., Yildirim, B. A., Yildirim, S. (2022): Effects of Hypericum scabrum L. essential oil on wound healing in streptozotocin-induced diabetic rats. Cutaneous and Ocular Toxicology 41: 137-144.
[70] De Bock, M., Derraik, J. G. B., Brennan, C. M., Biggs, J. B., Morgan, P. E., Hodgkinson, S. C., Cutfield, W. S. (2013): Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PLoS One 8: e57622.
[71] Jemai, H., El Feki, A., Sayadi, S. (2009): Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats. Journal of Agricultural and Food Chemistry 57: 8798-8804.
[72] Benavente-Garcia, O., Castillo, J., Lorente, J., Ortuño, A. D. R. J., Del Rio, J. A. (2000): Antioxidant activity of phenolics extracted from Olea europaea L. leaves. Food Chemistry 68: 457-462.
[73] Poudyal, H., Campbell, F., Brown, L. (2010): Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate–, high fat–fed rats1–3. The Journal of Nutrition 140: 946-953.
[74] Bahrami, G., Izadi, B., Miraghaee, S. S., Mohammadi, B., Hatami, R., Sajadimajd, S., Batooie, N. (2021): Antidiabetic potential of the isolated fractions from the plants of Rosaceae family in streptozotocin-induced diabetic rats. Research in Ppharmaceutical Sciences 16: 505-515.
[75] Taheripak, G., Mohammadi-Noorani, A., Asghari, G. (2022): Notch signaling-induced cyclin d1 in diabetes ameliorating effects of the isolated polysaccharide from Rosa canina: In vitro and in vivo studies. Cell Biochemistry and Function 40: 935-945.
[76] Chrubasik, C., Roufogalis, B. D., Müller‐Ladner, U., Chrubasik, S. (2008): A systematic review on the Rosa canina effect and efficacy profiles. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 22: 725-733.
[77] Bakırel, T., Bakırel, U., Keleş, O. Ü., Ülgen, S. G., Yardibi, H. (2008): In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. Journal of Ethnopharmacology 116: 64-73.
[78] Ramadan, K. S., Khalil, O. A., Danial, E. N., Alnahdi, H. S., Ayaz, N. O. (2013): Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats. Journal of Physiology and Biochemistry, 69: 779-783.
[79] Benjamin, M. A. Z., Mokhtar, R. A. M., Iqbal, M., Abdullah, A., Azizah, R., Sulistyorini, L., Zakaria, Z. A. (2024): Medicinal plants of Southeast Asia with anti-α-glucosidase activity as potential source for type-2 diabetes mellitus treatment. Journal of Ethnopharmacology 330: 118239.
[80] Marles, R. J., Farnsworth, N. R. (1995): Antidiabetic plants and their active constituents. Phytomedicine, 2: 137-189.
[81] Kimura, T., Nakagawa, K., Kubota, H., Kojima, Y., Goto, Y., Yamagishi, K., Oikawa, S. (2007): Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. Journal of Agricultural and Food Chemistry 55: 5869-5874.
[82] Asad, M., Aslam, M., Munir, T. A., Nadeem, A. (2011): Effect of Acacia nilotica leaves extract on hyperglycaemia, lipid profile and platelet aggregation in streptozotocin induced diabetic rats. Journal of Ayub Medical College Abbottabad 23: 3-7.
[83] Stolf, A. M., Cardoso, C. C., Acco, A. (2017): Effects of silymarin on diabetes mellitus complications: a review. Phytotherapy Research 31: 366-374.
[84] Petrović, A., Madić, V., Stojanović, G., Zlatanović, I., Zlatković, B., Vasiljević, P., Đorđević, L. (2024): Antidiabetic effects of polyherbal mixture made of Centaurium erythraea, Cichorium intybus and Potentilla erecta. Journal of Ethnopharmacology 319: 117032.
[85] Salehi, B., Ata, A., V. Anil Kumar, N., Sharopov, F., Ramirez-Alarcon, K., Ruiz-Ortega, A., Sharifi-Rad, J. (2019): Antidiabetic potential of medicinal plants and their active components. Biomolecules 9: 551.
[86] Khan, N., Mukhtar, H. (2018): Tea Polyphenols in Promotion of Human Health. Nutrients 11: 39.
[87] Pivari, F., Mingione, A., Brasacchio, C., Soldati, L. (2019): Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients 11: 1837.
[88] Khazaei, M. K. M. R., Khazaei, M. R., & Pazhouhi, M. (2020): An overview of therapeutic potentials of Rosa canina: A traditionally valuable herb. WCRJ 7: e1580.
[89] Juhás, Š., Bukovská, A., Čikoš, Š., Czikková, S., Fabian, D., Koppel, J. (2009). Anti-inflammatory effects of Rosmarinus officinalis essential oil in mice. Acta Veterinaria Brno 78: 121-127.
[90] Warshafsky, S., Kamer, R. S., Sivak, S. L. (1993): Effect of garlic on total serum cholesterol: a meta-analysis. Annals of Internal Medicine 119: 599-605.
[91] Arumugam, S., Kavimani, S., Kadalmani, B., Ahmed, A.B., Akbar, M.A., Rao, M.V. (2008): Antidiabetic activity of leaf and callus extracts of Aegle marmelos in rabbit. ScienceAsia 34: 317-321.
[92] Lee, J., Noh, S., Lim, S., & Kim, B. (2021): Plant extracts for type 2 diabetes: From traditional medicine to modern drug discovery. Antioxidants 10: 81.
[93] Lokman, E. F., Saparuddin, F., Muhammad, H., Omar, M. H., Zulkapli, A. (2019): Orthosiphon stamineus as a potential antidiabetic drug in maternal hyperglycemia in streptozotocin-induced diabetic rats. Integrative Medicine Research 8: 173-179.
[94] Datar, S.P., Bhonde, R.R. (2011): Modeling Chick to Assess Diabetes Pathogenesis and Treatment. The Review of Diabetic Studies 8: 243–253.
[95] Sagiadinou, E. C., Karavia, E. A., Xepapadaki, E., Zvintzou, E., Hatziri, A., Karampela, D. S., Kypreos, K. E. (2022). Benefits of a fixed-dose combination of standardized P. mume extract with choline on adipose tissue mitochondrial metabolic activity and pancreatic β-islet secretory capacity in mice. Phytomedicine Plus 2: 100317.
[96] Pandey, A., Tripathi, P., Pandey, R., Srivatava, R., Goswami, S. (2011): Alternative therapies useful in the management of diabetes: A systematic review. Journal of Pharmacy and Bioallied Sciences 3: 504-512.
[97] Nabi, F., Shi, D., Wu, Q., & Baloch, D. M. (2023). Treatment of animal diseases with veterinary phytotherapy. Frontiers in Veterinary Science 10: 1171987.
[98] Yam, M. F., Lim, C. P., Fung Ang, L., Por, L. Y., Wong, S. T., Asmawi, M. Z., Ahmad, M. (2013): Antioxidant and toxicity studies of 50% methanolic extract of Orthosiphon stamineus Benth. BioMed Research International, 2013: 351602.
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