INDUSTRIAL HEMP SEED: PRODUCTION, CHEMICAL CONTENT AND POTENTIAL USES FOR HUMAN NUTRITION
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Cannabis sativa L., Food ingredients, Hemp seed, Hemp seed proteinAbstract
Cannabis sativa L., also referred to as industrial hemp, is used to make a variety of goods. C. sativa L. strains with delta-9-tetrahydrocannabinol (D9-THC or THC) values less than 0.3% are considered industrial hemp. Industrial hemp has become widely accepted as an agricultural commodity over the past 20 years. Due to their great nutritional value, hemp seeds are already utilized as food additives in many different foods. The growth of the food industry is also supported by using seeds as nutraceuticals. An overview of cannabis cultivation around the world, the nutritional value of hemp seeds (proteins, lipids, vitamins, carbs, and minerals), the bioactive phytocannabinoids, phenolics, and flavonoids of hemp seeds, and their potential applications as food will all be covered in this review. The primary goal of this review is to discuss how industrial hemp seeds might be used in the food industry.
References
Bouloc, P. (2013). Hemp: industrial production and uses. CABI International, Oxfordshire, Wallingford, UK, 312.
Faux, A. M., Berhin, A., Dauguet, N., Bertin, P. (2014). Sex chromosomes and quantitative sex expression in monoecious hemp (Cannabis sativa L.). Euphytica, 196: 183-197.
Ranalli, P., Venturi, G. (2004). Hemp as a raw material for industrial applications. Euphytica, 140: 1-6.
Allegret, S. (2013). The history of hemp. In: Bouloc P, Allegret S, Arnaud, L. (eds.) Hemp Industrial Production and Uses, Chapter 2. CABI International, Oxfordshire, Wallingford, UK, pp.1-3.
Russo, E. B. (2007). History of cannabis and its preparations in saga, science, and sobriquet. Chemistry and Biodiversity 4: 1614-1648.
Apostol, L. (2017). Studies on using hemp seed as functional ingredient in the production of functional food products. Journal of Ecoagritourism, 13:12-17.
Frassinetti, S., Moccia, E., Caltavuturo, L., Gabriele, M., Longo, V., Bellani, L., Giorgi, G., Giorgetti, L. (2018). Nutraceutical potential of hemp (Cannabis sativa L.) seeds and sprouts. Food Chemistry, 262: 56-66.
Tutek, K., Masek, A. (2022). Hemp and its derivatives as a universal industrial raw material (with Particular Emphasis on the Polymer Industry)-A Review. Materials, 15(7): 2565.
Vonapartis, E., Aubin, M.P., Seguin, P., Mustafa, A.F., Charron, J.B. (2015). Seed composition of ten industrial hemp cultivars approved for production in Canada. Journal of Food Composition and Analysis, 39: 8-12.
Farinon, B., Molinari, R., Costantini, L., Merendino, N. (2020). The seed of industrial hemp (Cannabis sativa L.): nutritional quality and potential functionality for human health and nutrition. Nutrients, 12: 1-60.
Callaway, J.C. (2004). Hempseed as a nutritional resource: An overview. Euphytica, 140: 65-72.
Rehman, M., Fahad, S., Du, G., Cheng, X., Yang, Y., Tang, K., Deng, G. (2021) Evaluation of hemp (Cannabis sativa L.) as an industrial crop: A review. Environmental Science and Pollution Research, 28(38): 52832-52843.
Faostat, (2023). Food and agricultural data, hhtps://www.fao.org/faostat/en/#home. (Access Date: March 18 2023).
Agreste, (2022). Chiffres agricole annuelle, Republique Française November 2021, No:15.
Anonymous, (2023a). Agriculture and rural development. https://agriculture.ec.europa.eu/farming/crop-productions-and-plant-based products/hemp_en (Access Date: March 18 2023).
Anonymous, (2023b). Canada.ca. The official website of the Goverment of Canada. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/producing-selling-hemp/commercial-licence/list-approved-cultivars-cannabis-sativa.html. (Access Date: March 18 2023).
Anonymous, (2019). Harvested Daily. CDA-approved Certified Hemp Seed Varieties. Morning Ag Clips Farming News (Access Date: May 24 2023).
Laurence, H. (2020). European Parliament AMENDMENTS, 106-314.
Coppess, J., Schnitkey, G., Zulauf, C., Paulson, N., Gramig, B., Swanson, K. (2018). The agriculture improvement act of 2018: Initial Review. Farmdoc Daily, 8(227).
Giupponi, L., Leoni, V., Carrer, M., Ceciliani, G., Sala, S., Panseri, S., Giorgi, A. (2020). Overview on Italian hemp production chain, related productive and commercial activities and legislative framework. Italian Journal of Agronomy, 15(3): 194-205.
Marzen, C.G. (2018). The 2018 Farm bill: Legislative compromise in the trump era. Fordham Environmental Law Review, 30,49.
Fischer, B., Ala-Leppilampi, K., Single, E., Robins, A. (2003). Cannabis law reform in Canada: Is the" Saga of PROMISE, hesitation and Retreat" coming to an end? 1. Canadian Journal of Criminology and Criminal Justice, 45(3): 265-298.
UNODC. (2009). Recommended methods for the identification and analysis of cannabis and cannabis products (manual). United Nations, New York, pp:1-47.
Small, E. (2016). Cannabis: A complete guide. Boca Raton, CRC Press, pp: 1-541.
Crescente, G., Piccolella, S., Esposito, A., Scognamiglio M, Fiorentino, A., Pacifico, S. (2018): Chemical composition and nutraceutical properties of hempseed: An ancient food with actual functional value. Phytochemistry Reviews, 17(4): 733-749.
Zhang, Q., Chen, X., Guo, H., Trindade, L.M., Salentijn, E.M., Guo, R., Yang, M. (2018). Latitudinal adaptation and genetic insights into the origins of Cannabis sativa L. Frontiers in Plant Science, 9: 1876.
Small, E., Brookes, B. (2012). Temperature and moisture content for storage maintenance of germination capacity of seeds of industrial hemp, marijuana, and ditchweed forms of Cannabis sativa. Journal of Natural Fibers, 9(4): 240-255.
Small, E., Pocock, T., Cavers, P.B. (2003). The biology of Canadian weeds. 119. Cannabis sativa L. Canadian Journal of Plant Science, 83(1): 217-237.
Rana, A., Choudhary, N. (2010). Floral biology and pollination biology of Cannabis sativa L. International Journal of Plant Reproductive Biology, 2(2): 191-195.
Clarke, R.C., Watson, D.P. (2007). Cannabis and natural Cannabis medicines, In: Mahmoud A. ElSohly (Ed), Marijuana and the Cannabinoids 1-17. Humana Press, Springer, New York.
Leonard, W., Zhang, P., Ying, D., Fang, Z. (2020). Hempseed in food industry: nutritional value, health benefits, and industrial applications. Comprehensive Reviews in Food Science and Food Safety, 19: 282–308.
Burton, R.A., Andres, M., Cole, M., Cowley, J.M., Augustin, M.A. (2022). Industrial hemp seed: from the field to value-added food ingredients. Journal of Cannabis Research, 4(1):1-13.
House, J.D., Neufeld, J., Leson, G. (2010). Evaluating the quality of protein from hemp seed (Cannabis sativa L.) products through the use of the protein digestibility-corrected amino acid score method. Journal of Agricultural and Food Chemistry, 58: 11801-11807.
Schultz, C.J., Lim, W.L., Khor, S.F., Neumann, K.A., Schulz, J.M., Ansari, O., Burton, R.A. (2020). Consumer and health-related traits of seed from selected commercial and breeding lines of industrial hemp, Cannabis sativa L. Journal of Agriculture and Food Research, 2:100025.
Yano, H., Fu, W. (2023). Hemp: A sustainable plant with high industrial value in food processing. Foods, 12(3): 651-655.
Wieser, H., Koehler, P., Scherf, K.A. (2020). The two faces of wheat. Frontiers in Nutrition, 7: 517313.
El-Sohaimy, S.A., Androsova, N.V., Toshev, A.D., El Enshasy, H.A. (2022). Nutritional quality, chemical, and functional characteristics of hemp (Cannabis sativa ssp. Sativa) protein isolate. Plants, 11(21): 2825.
Tang, C.H., Ten, Z., Wang, X.S., Yang, X.Q. (2006). Physicochemical and functional properties of hemp (Cannabis sativa L.) protein isolate. Journal of Agricultural and Food Chemistry, 54: 8945-8950.
Jagdale, Y.D., Mahale, S.V., Zohra, B., Nayik, G.A., Dar, A.H., Khan, K.A. (2021). Nutritional profile and potential health benefits of süper foods: a review. Sustainability, 13: 9240-9270.
Montero, L., Ballesteros-Vivas, D., Gonzalez-Barrios, A. F., del Pilar Sánchez-Camargo, A. (2022). Hemp seeds: Nutritional value, associated bioactivities and the potential food applications in the Colombian context. Frontiers in Nutrition, 9: 1039180.
Cerino, P., Buonerba, C., Cannazza, G., D’Auria, J., Ottoni, E., Fulgione, A., Di Stasio, Pierri, B., Gallo, A., (2021). A review of hemp as food and nutritional supplement. Cannabis and Cannabinoid Research 6(1): 19-27.
Galasso, I., Russo, R., Mapelli, S., Ponzoni, E., Brambilla, I. M., Battelli, G., (2016). Variability in seed traits in a collection of Cannabis sativa L. genotypes Front Plant Sci., 7: 688.
Vonapartis, A.P. (2008). The importance of the omega-6/ omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine, 233: 674-688.
Leizer, C., Ribnicky, D., Poulev, A., Dushenkov, S., Raskin, I. (2000). The composition of hemp seed oil and its potential as an important source of nutrition. Journal of Nutraceuticals, Functional and Medical Foods, 2(4): 35-53.
Irakli, M., Tsaliki, E., Kalivas, A., Kleisiaris, F., Sarrou, E., Cook, C. M. (2019). Effect of genotype and growing year on the nutritional, phytochemical, and antioxidant properties of industrial hemp (Cannabis sativa L) seeds. Antioxidants, 8: 491.
Potin, F., Saurel, R. (2020). Hemp seed as a source of food proteins. Sustainable Agriculture Reviews, 42: 265.
Mattila, P., Makinen, S., Eurola, M., Jalava, T., Pihlava, J. M., Hellstrom, J. (2018). Nutritional value of commercial protein-rich plant products. Plant Foods for Human Nutrition, 73: 108-155.
Pojic, M., Hadnadev, T.D., Hadnagev, M., Rakita, S., Brlek, T. (2015). Bread supplementation with hemp seed cake: a byproduct of hemp oil processing. Journal of Food Quality, 38:431-440.
Oseyko, M., Sova, N., Lutsenko, M., Kalyna, V. (2019). Chemical aspects of the composition of industrial hemp seed products. Ukranian Food Jounal, 8(3): 544-558.
Pavlovic, R., Panseri, S., Giupponi, L., Leoni, V., Citti, C., Cattaneo, C. (2019). Phytochemical and ecological analysis of two varieties of hemp (Cannabis sativa L.) grown in a mountain environment of Italian alps. Frontiers in Plant Science, 10: 1265.
Sun, X., Sun, Y., Li, Y., Wu, Q., Wang, L. (2021). Identification and characterization of the seed storage proteins and related genes of Cannabis sativa L. Frontiers in Nutrition, 8: 678421.
Docimo, T., Caruso, I., Ponzoni, E., Mattana, M., Galasso, I. (2014). Molecular characterization of edestin gene family in Cannabis sativa L. Plant Physiology and Biochemistry, 84: 142–148.
Patel, S., Cudney, R., McPherson, A. (1994). Crystallographic characterization and molecular symmetry of edestin, a legumin from hemp. Journal of Molecular Biology, 235: 361-363.
Malomo, S.A., Aluko, R.E. (2015). A comparative study of the structural and functional properties of isolated hemp seed (Cannabis sativa L.) albumin and globulin fractions. Food Hydrocolloids, 43: 743-752.
Kahraman, O., Petersen, G.E., Fields, C. (2022). Physicochemical and functional modifications of hemp protein concentrate by the application of ultrasonication and pH shifting treatments. Foods, 11: 587.
Odani, S., Odani, S. (1998). Isolation and primary structure of a methionine- and cystine-rich seed protein of Cannabis sativa. Bioscience, Biotechnology, and Biochemistry, 62: 650-654.
Wu, G., Bazer, F.W., Davis, T.A., Kim, S.W., Li, P., Rhoads, J.M. (2009). Arginine metabolism and nutrition in growth, health and disease. Amino Acids, 37: 153-168.
Russo, R., Reggiani, R. (2015): Evaluation of protein concentration, amino acid profile and anti-nutritional compounds in hempseed mealfrom dioecious and monoecious varieties. American Journal of Plant Sciences, 6: 14-22.
Wu, G., Meininger, C.J. (2002). Regulation of nitric oxide synthesis by dietary factors. Annual Review of Nutrition, 22:61-86.
Pojić, M., Mišan, A., Sakač, M., Dapčević Hadnađev, T., Šarić, B., Milovanović, I., Hadnađev, M. (2014). Characterization of byproducts originating from hemp oil processing. Journal of Agricultural and Food Chemistry, 62(51): 12436-12442.
Wang, Q., Jiang, J., Xiong, Y.L. (2018). High pressure homogenization combined with pH shift treatment: a process to produce physically and oxidatively stable hemp milk. Food Reserach International, 106: 487–494.
Wang, Q., Jiang, J., Xiong, Y.L. (2019). Genipin-aided protein cross-linking to modify structural and rheological properties of emulsion-filled hempseed protein hydrogels. Journal of agricultural and food chemistry, 67(46): 12895-12903.
Mazorra-Manzano, M.A., Ramirez-Suarez, J.C., Yada, R.Y. (2018). Plant proteases for bioactive peptides release: A review. Critical Reviews in Food Science and Nutrition, 58:2147-2163.
Mamone, G., Picariello, G., Ramondo, A., Nicolai, M.A., Ferranti, P. (2019). Production, digestibility and allergenicity of hemp (Cannabis sativa L.) protein isolates. Food Research International, 115: 562-571.
Banskota, A.H., Tibbetts, S.M., Jones, A., Stefanova, R., Behnke, J. (2022). Biochemical characterization and in vitro digestibility of protein isolates from hemp (Cannabis sativa L.) byproducts for salmonid feed applications. Molecules, 27: 4794.
Da Silva, B.P., Anunciação, P.C., da Silva Matyelka, J.C., Della Lucia, C.M., Martino, H. S.D., Pinheiro-Sant’Ana, H. M. (2017). Chemical composition of Brazilian chia seeds grown in different places. Food Chemistry, 221: 1709-1716.
Taaifi, Y., Benmoumen, A., Belhaj, K., Aazza, S., Abid, M., Azeroual, E. (2021). Seed composition of non-industrial hemp (Cannabis sativa L.) varieties fromfour regions in northern Morocco. International Journal of Food Science and Technology, 56: 5931–5947.
Devi, V., Khanam, S. (2019). Study of &-6 linoleic and &-3 a-linolenic acids of hemp (Cannabis sativa) seed oil extracted by supercritical CO2 extraction: CCD optimization. Journal of Enviromental Chemistry Engineering, 7: 102818.
Siano, F., Moccia, S., Picariello, G., Russo, G.L., Sorrentino, G., Di Stasio M. (2019) Comparative study of chemical, biochemical characteristic and ATR-FTIR analysis of seeds, oil and flour of the edible fedora cultivar hemp (Cannabis sativa L). Molecules 24: 83.
Babiker, E.E., Uslu, N., Al Juhaimi, F., Ahmed, I.A.M., Ghafoor, K., Özcan, M.M. (2021). Effect of roasting on antioxidative properties, polyphenol profile and fatty acids composition of hemp (Cannabis sativa L) seeds. LWT 139:110537.
Kriese, U., Schumann, E., Weber, W.E., Beyer, M., Brühl, L. (2004). Oil content, tocopherol composition and fatty acid patterns of the seeds of 51 Cannabis sativa L. genotypes. Euphytica, 137:339-351.
Soetan, K.O., Olaiya, C.O., Oyewole, O.E. (2010). The importance of mineral elements for humans, domestic animals and plants-A review. African Journal Food Science, 4: 200-222.
Lan, Y., Zha, F., Peckrul, A., Hanson, B., Johnson, B., Rao, J. (2019). Genotype x environmental effects on yielding ability and seed chemical composition of industrial hemp (Cannabis sativa L) varieties grown in North Dakota, USA. Journal of American Oil Chemistry Society 96: 1417-1425.
Zuk-Golaszewska, K., Golaszewski, J. (2018). Cannabis sativa L.–cultivation and quality of raw material. Journal of Elementology, 23: 3.
Strzelczyk, M., Gimbut, M., Łochyńska, M. (2023). Nuts of Fibrous Hemp Cannabis sativa L.-Concentrated Power of Nutrients. Journal of Natural Fibers, 20(1): 2128967.
Alonso-Esteban, J.I., Pinela, J., Ciric, A., Calhelha, R.C., Sokovi´c, M., Ferreira, I.C.F.R., Barros, L., Torija-Isasa, E., S´anchez-Mata, M.C., (2022). Chemical composition and biological activities of whole and dehulled hemp (Cannabis sativa L.) seeds. Food Chemistry, 374: 131754.
Romero-Aguilera, F., Alonso-Esteban, J.I., Torija-Isasa, M.E., C´amara, M., S´anchez- Mata, M.C. (2017). Improvement and validation of phytate determination in edible seeds and derived products, as mineral complexing activity. Food Analytical Method, 10: 3285-3291.
Dahdouh, D., Grande, F., N´ajera-Espinosa, S., Vincent, A., Gibson, R., Bailey, K., King, J., Rittenschober, D., Charrondi`ere, U.R. (2019). Development of the FAO/INFOODS/IZINCG global food composition database for phytate. Journal of Food Composition and Analysis, 78: 42-48.
Guil, J.L., Torija, M.E., Gim´enez, J.J., Rodríguez-García, I., Gim´enez, A. (1996). Oxalic acid and calcium determination in wild edible plants. Journal of Agricultural and Food Chemistry, 44: 1821-1823.
Viswanathan, M.B., Par K., Cheng, M.H., Cahoon, E.B., Dweikat, I., Clemente, T. (2020). Variability in structural carbohydrates, lipidcomposition, and cellulosic sugar production from industrial hemp varieties. Industrial Crops and Products 157: 112906.
Flores-Sánchez I.J., Verpoorte, R. (2008). Secondary metabolism in cannabis Phytochemistry Review, 7: 615-639.
Small, E., Naraine, S.G.U. (2016). Size matters: evolution of large drug-secreting resin glands in elite pharmaceutical strains of Cannabis sativa (marijuana). Genetic Resources and Crop Evolution, 63: 349-359.
Agriculture Improvement Act, (2018). An act to provide for the reform and continuation of agricultural and other programs of the Department of Agriculture through fiscal year 2023, and for other purposes. Retrieved May 27, 2021. https://www.congress.gov/bill/115th-congress/house-bill/2.
Moran, C. (2015). Fordham environmental law review industrial hemp: Canada exports, United States imports. Fordham Enviromental Law Rewiev, 26: 3.
Kanabus, J., Bryła, M., Roszko, M., Modrzewska, M., Pierzgalski, A. (2021). Cannabinoids—Characteristics and potential for use in food production. Molecules, 26: 6723.
Andre, C.M., Hausman, J.F., Guerriero, G. (2016). Cannabis sativa: The plant of the thousand and one molecules. Fronteirs Plant Science, 7: 19.
Smeriglio, A., Galati, E.M., Monforte, M.T., Lanuzza, F., D’Angelo, V., Circosta, C. (2016). Polyphenolic compounds and antioxidant activity of cold-pressed seed oil from finola cultivar of Cannabis sativa L. Phytotheraphy Research, 30: 1298-1307.
Norajit, K., Gu, B. J., Ryu, G. H. (2011). Efects of the addition of hemp powder on the physicochemical properties and energy bar qualities of extruded rice. Food Chemisrty, 129: 1919–1925.
Crini, G., Lichtfouse, E., Chanet, G., Morin-Crini, N. (2020). Applications of hemp in textiles, paper industry, insulation and building materials, horticulture, animal nutrition, food and beverages, nutraceuticals, cosmetics and hygiene, medicine, agrochemistry, energy production and envi¬ronment: A review. Environmental Chemistry Letters, 18: 1451-1476.
Praise Hemp. (2022.: Available online at: https://praisehemp.ca (Accessed April 10, 2023).
Nutiva, R. (2022). Available online at: www.nutiva.com (Accessed April 10, 2023).
Canah, R. (2022). Available online at: https://www.canah.com (Accessed April 10, 2023).
Ascrizzi, R., Iannone, M., Cinque, G., Marianelli, A., Pistelli, L., Flamini, G. (2020): “Hemping” the drinks: Aromatizing alcoholic beverages with a blend of Cannabis sativa L. flowers. Food Chemistry, 325: 126909.
Xu, J., Bai, M., Song, H., Yang, L., Zhu, D., Liu, H. (2022). Hemp (Cannabis sativa subsp. sativa) Chemical composition and the application of hempseeds in food formulations. Plant Foods for Human Nutrition, 77(4): 504-513.
Shaghaghian, S., McClements, D.J., Khalesi, M., Garcia-Vaquero, M., Mirzapour-Kouhdasht, A. (2022). Digestibility and bioavailability of plant-based proteins intended for use in meat analogues: A review. Trends Food Science and Technology, 129:646-656.
Younis, K., Ashfaq, A., Ahmad, A., Anjum, Z., Yousuf, O. (2022). A critical review focusing the effect of ingredients on the textural properties of plant-based meat products. Journal of Texture Study, 1-18.
Boukid, F. (2021). Plant-Based Meat Analogues: From Niche to Mainstream. European Food Reserach Technology, 247: 297-308.
Dai, H., An, H. (2022). Effects of cysteine on physicochemical properties of high-moisture extrudates prepared from plant protein. Foods, 11: 3109.
Rusu, I.E., Mureşan, C.C., Mureşan, A.E., Mureşan, V., Pop, C.R., Chiş, M.S. (2021). Hemp (Cannabis sativa L.) four-based wheat bread as fortifed bakery product. Plants 10: 1558.
Pojić, M., Dapčević Hadnađev, T. Hadnađev, M., Rakita, S., Brlek, T. (2015). Bread supplementation with hemp seed cake: a byproduct of hemp oil processing. Journal of Food Quality, 38: 431–440.
Korus, J., Witczak, M., Ziobro, R., Juszczak, L. (2017). Hemp (Cannabis sativa subsp. sativa) four and protein preparation as natural nutrients and structure forming agents in starch based gluten-free bread. LWT Food Science Technology, 84: 143-150.
Ertaş, N., Aslan, M. (2020). Antioxidant and physicochemical properties of cookies containing raw and roasted hemp four. Acta Scientiarum Polonorum Technologia Alimentaria, 19(2): 177-184.
Mikulec, A., Kowalski, S., Sabat, R., Skoczylas, L., Tabaszewska, M., Wywrocka-Gurgul, A. (2019). Hemp flour as a valuable component for enriching physicochemical and antioxidant properties of wheat bread. LWT Food Science Technology, 102: 164-172.
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