THE ROLE AND PROFILING OF MIRNA'S IN THE PROCESS OF CARCINOGENESIS WITH NANOTECHNOLOGY
Özet Görüntüleme: 334 / PDF İndirme: 181Anahtar Kelimeler:
miRNA, - Kanser, - RNA, - Nanoteknoloji, - Onkogen, - Terapötik, - Tümör süpresörÖzet
MikroRNA'lar (miRNA'lar), protein kodlayan genlerin, çeşitli onkogenlerin veya tümör baskılayıcı genlerin ekspresyonunu düzenleyen, protein kodlamayan küçük RNA'ların çok yeni bir sınıfıdır. Farklı kanser türlerinde farklı aşamalarda farklı miRNA'ların benzersiz ekspresyon profilleri, miRNA'ların hastalık teşhis ve tedavisi için yeni biyobelirteçler olarak işlev görebileceğini ve miRNA gen tedavisi için yeni bir strateji sunabileceği düşünülmektedir. miRNA'nın normal hücresel ve hastalık süreçlerindeki rolünü araştırmak son yıllarda, bilim insanları arasında oldukça popüler olmuştur. MiRNA'ların ekspresyon profili, kanser hastalarında tümör başlangıcını, ilerlemesini ve tedaviye yanıtı değerlendirmek için teşhis ve prognostik biyobelirteçler olarak kanser kliniklerine girmiştir. Anti-miRNA'lar ve antisenseoligonükleotitler, araştırma ve klinik amaçlar için in vitro ve in vivo olarak spesifik miRNA ekspresyonunu inhibe etmek için kullanılmıştır. Bu derlemede, miRNA’ların kanserle ilişkisi (aşağı/yukarı regülasyonu), onkogenler veya tümör baskılayıcılar olarak görevleri, terapötikler olarak kullanımı ve nanoteknoloji destekli miRNA teknolojisinden bahsedilmiştir.
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