A REVIEW ON THE EFFECTS OF Cannabis sativa L. ON HUMAN COGNITION
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Cannabis, Cannabinoid, Alzheimer's, Marijuana, MemoryAbstract
Natural resources have been an important starting point in the medical and pharmaceutical sciences for the discovery of drug candidates. Cannabis sativa, a plant of the Cannabidaceae family, is regarded as the first psychoactive substance to be consumed. The use of cannabis has been shown to have positive effects on a variety of chronic conditions, including cancer, AIDS, and Alzheimer's. Consequently, legalizing cannabis use for both therapeutic and recreational purposes is currently the subject of heated controversy in numerous nations. C. sativa contains about 540 natural compounds known as phytocannabinoids. Among these compounds, cannabinol-type cannabidiol (CBD) and trans-Δ9-tetrahidrocannabinol (THC) are more researched than other components. According to literature studies, it is known that the dominant psychotropic component in the species is trans-Δ9-tetrahidrokanabinol, while the main non-psychoactive component is cannabidiol. In addition to its many traditional medical applications, cannabis has been shown to be effective against Alzheimer's disease-related cognitive dysfunction in numerous in vitro and in vivo investigations. Future research on cannabis extracts and components should, according to both in vitro and in vivo studies, focus on the potential advantages of cannabis extracts for both animal and human brain-cognitive health. In order to fully demonstrate the effects of cannabis and its various preparations on human cognition, longer-term clinical studies with larger numbers of subjects are needed.
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