Oksidatif Mitokondrial Hasar ve Yaşlanmadaki Önemi

Abstract

Reactive oxygen metabolites (ROMs) or free radicals are formed by mitochondria in all aerobic organisms as a product
of normal metabolism in mitochondria and cause damage to macromolecules. Mitochondria are most vulnerable against these
radicals in cells and ATP production decline as a result of mitochondrial dysfunction. It has recently been demonstrated that
accumulation of oxidative damages with age has a significant role in apoptosis, some late-life diseases and aging process.
Actually cells possess antioxidant defense mechanisms that detoxify free radicals. Because the defense mechanisms are
inadequate during the aging process, oxidative damages are accumulated and cause diseases and aging. Anyway, sole cause
of aging is not reduced to free oxygen radicals owing to the fact that aging is probably a multifactorial process.